Hossein Mashhadi-Abdolahi
1 
, Roya Darbani
2, Oldouz Rabet
2, Asal Golchin
3 , Sorayya Kheirouri
4 , Mohammad Alizadeh
5 , Mehran Mesgari-Abbasi
2* 1 Tabriz Health Services Management Research Center, Tabriz, Iran
2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4 Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
5 Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
The majority of the body’s organs are impacted by ambient air pollution (AAP), which is currently a serious environmental global health issue. The objective of this work was to assess the impact of ozone (O3 ), sulfur dioxide (SO2 ), and AAP on oxidative stress (OS) and lipid profile indicators in male Wistar rats. To this end, these rats were exposed for three hours each day for five weeks in control, AAP, O3 (0.6 ppm), and SO2 (10 ppm) groups (each containing 8 animals). Several parameters, such as total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, and malondialdehyde (MDA), were measured on blood samples. AAP exposure on TAC (P=0.014) and SOD (P=0.05), MDA (P=0.018), and HDL (P=0.003), O3 exposure on TAC (P<0.001), and SO2 exposure on blood serum TAC (P=0.006) all had statistically significant effects. Based on the results, exposure to SO2 and AAP did not significantly alter the lipid profile (P>0.05). According to our research, exposure to O3 , SO2 , and AAP can increase overall antioxidant capacity by stimulating blood serum oxidative defense enzymes. Except for the enhanced effect of O3 exposure on serum HDL, AAP, SO2 , and O3 exposures had no discernible effects on the lipid profile.