Submitted: 29 Oct 2015
Revised: 15 Nov 2015
Accepted: 15 Dec 2015
First published online: 13 Aug 2018
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Avicenna J Environ Health Eng. 2015;2(2):4541-4541.
doi: 10.17795/ajehe-4541
  Abstract View: 67
  PDF Download: 72


The Potential of Bdellovibrio For the Biocontrol of the Infectious Agent Vibrio cholerae

Natalia Olsson Markelova *

1 Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, Russia
2 University of Maryland Biotechnology Institute, Baltimore, Maryland, USA
Corresponding author: Natalia Olsson Markelova, Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, Russia. Email:


Members of the genus Bdellovibrio are small and highly motile Gram-negative predators of other Gram-negative bacteria. Bdellovibrio enters the prey cell, transforming it into a structure that is referred to as a bdelloplast. It then grows and divides inside the bdelloplast, ending in lysis and the release of the Bdellovibrio progeny. Because of this capability, Bdellovibrio is a potential antibacterial agent. In this article, we report the results of studies on the interactions of Bdellovibrio with actively growing and viable but nonculturable (VBNC) Vibrio cholerae. A significant observation was that Bdellovibrio attacked both VBNC and actively growing V. cholerae. These results indicate that Bdellovibrio, a "living antibiotic," has potential as an antibacterial agent in environmental and public health bioprotection.
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