Submitted: 16 Apr 2020
Revision: 11 Jun 2020
Accepted: 21 Jun 2020
ePublished: 29 Jun 2020
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Avicenna J Environ Health Eng. 2020;7(1): 1-7.
doi: 10.34172/ajehe.2020.01
  Abstract View: 237
  PDF Download: 124

Original Article

Toxicological Effects of Silver Nanoparticles on Nile Tilapia (Oreochromis niloticus)

Farahnaz Kakavand 1, Aliakbar Hedayati 1* ORCID logo, Ali Jafar Nodeh 1, Saeid Maddah 2, Maryam Rezaei Shadegan 1

1 Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
2 Faculty of Environmental Sciences, Tehran University, Tehran, Iran.


The wide use of nano-sized metallic materials could result in the release of these particles into the environment. In addition, due to the dissolution of these nano-materials, some of the adverse effects could result from the dissolved metals. On the other hand, dietary supplements play a key role in improving the immunity of consumers; hence, the use of immune stimulants such as mushroom seems to be very necessary. In this study, the dietary effect of Pleurotus ostreatus mushroom was investigated on serum immunity and liver histopathological indices of Oreochromis niloticus exposed to silver nanoparticles (AgNPs). Serum total protein level enhanced with increasing prebiotic concentration. Serum immunoglobulin and albumin levels increased in the group treated with Pleurotus ostreatus. The amount of these indices significantly increased at the concentration of 0.2 mg/kg; however, glucose value decreased in both of the experimental groups. Serum ALT and ALP levels significantly reduced in the combined treatment group (AgNPs and mushroom) at the concentration of 0.2 mg/kg, in contrast with the control group. In the combination treatment group (AgNPs and mushroom), the serum AST level significantly reduced at concentrations of 0.1 mg/kg and 0.2 mg/kg; however, it increased at the concentration of 0.05 mg/kg compared with the control group, indicating that immunological indices could improve due to the combined use of AgNPs and mushroom. The overall conclusion of this study shows that the use of mushroom at 0.2 mg/kg in combination with AgNPs could partially improve the effect of AgNPs on tilapia.
Keywords: Aquatic pollution, Resistance improvement, Metal nanoparticles, Pleurotus ostreatus,
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